ARMs Lab - Rivero-Müller's group

Research Group members

Adolfo Rivero-Müller, MD, PhD, Prof.

Principal Investigator

Jakub Czapiński, PhD; Soumya Menon, PhD; Lidia Borkiewicz, PhD; Karolina Dudziak, PhD

Members of the research group

Thu Ha Ngo; Volodymyr Shynkivskyi; Krystian Łopucki (UMCS); Joanna Kałafut; Kamila Szymanska; Alicja Przybyszewska-Podstawka

PhD students


Ashutosh Trehan PhD (defended PhD in September 2016) currently a scientist fellow at Astra Zeneca, Cambridge, UK.

Valeriy Paramonov PhD (defended PhD in August 2021) currently a postdoc at the lab of Prof, Karolinska Institute, Sweden.

Description of research

Research interests in brief

Our ultimate goal is to understand how living organisms function. With this aim we work on cell function as well as cell control using many different cutting-edge molecular biology techniques.

Every cell in the body of a multicellular organism has all the information to create a clone of the same organism. They have all the instructions such as growing, migrating and dividing, yet, instead cells organise and differentiate into all the different tissues in our bodies. This means that cells follow a programme where some of their activities are repressed while others are activated. How cells communicate with each other and make decision on what each cells will become is something we are just starting to understand. Moreover, cells “remember” such instructions and can pass the information to the next generation of cells when they divide.

Our group’s research focus is the understanding of how cells make decisions at the molecular level, and more importantly how we can manipulate the key players: proteins and RNA, in a way that we can control the activity and fate of cells. In other words, we not only want to understand the molecular mechanisms but we would like to be able to programme cells and in some cases change their fate, for example stopping cancer cells from migrating.

Cells are extremely complex and the networks of interactions within cells is overwhelming. Thus, we use cutting-edge molecular biology techniques to be able to manipulate cells at all levels (DNA, RNA, Protein) and modern synthetic biology tools such as proteins that get activated or inactivated by light, RNA that acts as scaffold for protein complexes, or riboprotein complexes that are able to delete, replace or repair genes in cells.

As working with biological systems has many challenges, we also work in the development or improvement of molecular tools in order to study complex phenomena.


Job openings



Medical Sciences



Synthetic Biology, Cell-Cell Interactions, Cell Signalling, Receptor, Ligand, Pathway, Cell Communication, Optogenetics, Translation, GPCR, Notch, Logic Gate, Molecular Tools, Gene Editing


Grants supporting our research

OPUS 9:  2015/17/B/NZ1/01777

Miniatura: 2017/01/X/NZ1/00107 (Michał Kiełbus)

OPUS 13: 2017/25/B/NZ4/02364

Preludium: 2018/29/N/NZ5/02670 (Kamila Szymanska)

Miniatura 2019/03/X/NZ4/01101 (Karolina Dudziak)

OPUS+LAP 2020:  UMO-2020/39/I/ST5/03560

Preludium: 2021/41/N/NZ5/01938 (Joanna Kałafut)

OPUS 23:     2022/45/B/NZ3/02353   (in consortium with UMCS)  

Akademickie Partnerstwa Międzynarodowe (International Academic Partnership) POLFINGERS

Prof. Walczak programme PPN/WAL/2020/1/00008 (Karolina Dudziak)

Translational control in Cancer European Network (TRANSLACORE) by COST (European Cooperation in Science and Technology) CA21154.



Alicja Przybyszewska-Podstawka, Jakub Czapiński, Joanna Kałafut, Adolfo Rivero-Müller (2023) Synthetic Circuits Based on Split Cas9 to Detect Cellular Events. Pre-print: bioRxiv 2023.03.16.533022; doi: Scientific Reports 13:14988

Kamila Adamczuk, Adolfo Rivero-Müller (2023) Glycoprotein-glycoprotein receptor binding detection using bioluminescence resonance energy transfer (BRET). Pre-print: bioRxiv 2023.01.21.525003; doi:

Alicja Przybyszewska-Podstawka, Joanna Kałafut, Jakub Czapiński, Thu Ha Ngo, Arkadiusz Czerwonka, Adolfo Rivero-Müller (2023) TANGO-Light – optogenetic control of transcriptional modulators. Pre-print: BioRxiv

Kamil Filipek, Kamil Deryło, Barbara Michalec-Wawiórka, Monika Zaciura, Alan González-Ibarra, Dawid Krokowski, Przemysław Latoch, Agata L Starosta, Jakub Czapiński, Adolfo Rivero-Müller, Leszek Wawiórka, Marek Tchórzewski (2023) Identification of a novel alternatively spliced isoform of the ribosomal uL10 protein. Biochim Biophys Acta Gene Regul Mech. 2023 Mar;1866(1):194890.  doi: 10.1016/j.bbagrm.2022.194890.

Kałafut J, Czapiński J, Przybyszewska-Podstawka A, Czerwonka A, Odrzywolski A, Sahlgren C, Rivero-Müller A (2022) Optogenetic control of NOTCH1 signalling. Pre-print at BioRxiv DOI: 10.1101/2021.09.27.462029. Cell Communication and Signaling 20(1):67. doi: 10.1186/s12964-022-00885-5.

Kałafut J, Czerwonka A, Anameriç A, Przybyszewska-Podstawka A, Misiorek JO, Rivero-Müller A, Matthias Nees (2021) Shooting at Moving and Hidden Targets – Tumour Cell Plasticity and the Notch Signalling Pathway in Head and Neck Squamous Cell Carcinomas. Cancers 13(24):6219. doi: 10.3390/cancers13246219.

Rivero-Muller A & Huhtaniemi I (2021) Genetic variants of gonadotrophins and their receptors: impact on the diagnosis and management of the infertile patient. Best Practice & Research: Clinical Endocrinology and Metabolism. Doi: 10.1016/j.beem.2021.101596.

Gumbarewicz E, Tylżanowski P, Łuszczki J, Kałafut J, Czerwonka A, Szumiło J, Wawruszak A, Kupisz K, Polberg K, Smok-Kalwat J, Stepulak A (2021) Differential molecular response of larynx cancer cell lines to combined VPA/CDDP treatment. Am J Cancer Res. 15;11(6):2821-2837. PMID: 34249430

Borkiewicz L, Kalafut J, Dudziak K, Przybyszewska-Podstawka A, Telejko I (2021) Decoding LncRNAs. Cancers (Basel) 13(11):2643. doi: 10.3390/cancers13112643.

Wawruszak A, Luszczki J, Halasa M, Okon E, Landor S, Sahlgren C, Rivero-Muller A, Stepulak A (2021) Sensitization of MCF7 cells with high Notch1 activity by cisplatin and histone deacetylase inhibitors applied together. International Journal of Molecular Sciences 22(10):5184. doi: 10.3390/ijms22105184.

Czapiński J, Kałafut J, Przybyszewska-Podstawka A, Pawlicka A, Roszkowska A, Kiełbus M, Borkiewicz L, Dudziak K, Czerwonka A, Stepulak A, Rivero-Muller A (2021) Development of a bioassay for continuous monitoring of TWIST1 activity. Preprints doi:10.20944/preprints202103.0265.v1.

Mung KL, Eccleshall W, Santio NM, Rivero-Müller A, Koskinen PJ (2021) Crosstalk between PIM and LKB1 kinases regulates AMPK phosphorylation and tumorigenic growth. Cell Communication and Signaling 19(1):68. doi: 10.1186/s12964-021-00749-4. (video abstract)

Michalec-Wawiórka B, Czapiński J, Filipek K, Rulak P, Czerwonka A, Tchórzewski M, Rivero-Müller A (2021) An improved vector system for homogeneous and stable gene regulation. International Journal of Molecular Sciences 22(10):5206. doi: 10.3390/ijms22105206

Misiorek JO, Przybyszewska-Podstawka A, Kałafut J, Paziewska B, Rolle K, Rivero-Müller A, Nees M (2021) Context Matters: NOTCH Signatures and Pathway in Cancer Progression and Metastasis. Cells 10(1):94. doi: 10.3390/cells10010094.

Landor SKJ, Santio NM, Eccleshall W, Mung KL, Paramonov V, Mamaeva V, Jin S-B, Rivero-Müller A, Lendahl U, Koskinen PJ, Sahlgren CM (2021) Pim kinase differentially phosphorylates Notch1 and 3 leading to Notch receptor-specific effects in breast cancer. J Biol Chem. doi: 10.1016/j.jbc.2021.100593

Hermanowicz JM, Szymanowska A, Sieklucka B, Czarnomysy R, Pawlak K, Bielawska A, Bielawski K, Kalafut J, Przybyszewska A, Surazynski A, Rivero-Muller A, Mojzych M, Pawlak D (2021) Exploration of novel heterofused 1,2,4-triazine derivative in colorectal cancer. J Enzyme Inhib Med Chem 36(1): 535-548. DOI:10.1080/14756366

Jonas KC, Rivero-Muller A, Oduwole O, Peltoketo H, Huhtaniemi IT (2021) The luteinizing hormone receptor knock-out mouse as a tool to probe the in vivo actions of gonadotropic hormones/receptors in females. Preprint at BioRxiv 2020.08.11.244467. DOI 10.1101/2020.08.11.244467. Endocrinology 162(5): bqab035.

Casarini L, Lazzaretti C, Paradiso E, Limoncella S, Riccetti L, Sperduti S, Melli B, Marcozzi S, Anzivino C, Sayers NS, Czapinski J, Brigante G, Potì F, La Marca A, De Pascali F, Reiter E, Falbo A, Daolio J, Villani MT, Lispi M, Orlando G, Klinger FG, Fanelli F, Rivero-Müller A, Hanyaloglu AC, Simoni M (2020) Membrane estrogen receptor (GPER) and follicle-stimulating hormone receptor heteromeric complexes promote human ovarian follicle survival. Preprint at BioRxiv 2020.04.21.053348 doi: Published in iScience 23, 101812. DOI:

Paramonov V, Sahlgren CM, Rivero-Müller A, Pulliainen A (2020) iGIST – a sensitive bioassay for pertussis toxin, based on its effect on inhibitory GPCR signaling. Preprint at BioRxiv 2020.09.29.318451; doi: 10.1101/2020.09.29.318451. Published at ACS Sensors. doi/10.1021/acssensors.0c01340

Paramonov V, Gerstenberg M, Sahlgren CM, Lindén M, Rivero-Müller A (2020) In vitro targetability validation of peptide-functionalized mesoporous silica nanoparticles in the presence of serum proteins. Front in Chem. 8:603616.  doi: 10.3389/fchem.2020.603616.

Rodríguez‑Rodríguez I, Kalafut J, Czerwonka A, Rivero‑Müller A (2020) A novel bioassay for quantification of surface Cannabinoid receptor 1 expression. Sci Reports 10:1819. DOI 10.1038/s41598-020-75331-y.

Grabarska A, Skalicka-Woźniak K, Kiełbus M, Dmoszyńska-Graniczka M, Miziak P, Szumiło J, Nowosadzka E, Kowalczuk K, Khalifa S, Smok-Kalwat J, Klatka J, Kupisz K, Polberg K, Rivero-Müller A, Stepulak A (2020) Imperatorin as a promising chemotherapeutic agent against human larynx cancer and rhabdomyosarcoma cell. Molecules 25(9), 2046. doi:10.3390/molecules25092046.

Rozkiewicz D, Hermanowicz JM, Tankiewicz-Kwedlo A, Sieklucka B, Pawlak K, Czarnomysy R, Bielawski K, Surazynski A, Kalafut J, Przybyszewska A, Koda M, Jakubowska K, Rivero-Muller A, Pawlak D (2020) The intensification of anticancer activity of LFM-A13 by erythropoietin as a possible option for inhibition of breast cancer. J Enzyme Inhib Med Chem 35(1):1697-1711. doi: 10.1080/14756366.2020.1818738.

Amoda A, Borkiewicz L, Rivero-Müller A, Alam P (2020) Sintered nanoporous biosilica diatom frustules as high efficiency cell-growth and bone-mineralisation platforms. Materials Today Communications, 100923.

Kiełbus M, Czapiński J, Kałafut J, Woś J, Stepulak S, Rivero-Müller A (2019) Genetical engineered lung cancer cell for analyzing Epithelial-Mesenchymal transition. Cells 5;8(12). pii: E1644. doi: 10.3390/cells8121644, as pre-print in bioRxiv 778316. doi 10.1101/778316.

Kalveram L, Kleinau G, Szymańska K, Scheerer P, Rivero-Müller A, Grüters-Kieslich A, Biebermann H (2019) The pathogenic TSH beta-subunit variant C105Vfs114X causes a modified signaling profile at TSHR. International Journal of Molecular Sciences 20, 5564. doi:10.3390/ijms20225564.

Rivero-Müller A and Nees M (2019). Preparing biomedical students for the unknown. EMBO Reports e49004. doi:10.15252/embr.201949004.

Wawruszak A, Gumbarewicz E, Okon E, Jeleniewicz W, Czapinski J, Halasa M, Okla K, Smok-Kalwat J, Bocian A, Rivero-Müller A, Stepulak A (2019). Histone deacetylase inhibitors reinforce the phenotypical markers of breast epithelial or mesenchymal cancer cells but inhibit their migratory properties. Cancer Management and Research 11:8345-8358. doi: 10.2147/CMAR.S210029.

van Engeland NCA, Suarez Rodriguez F, Rivero-Müller A, Ristori T, Duran CL, Stassen OMJA, Antfolk D, Driessen RCH, Ruohonen S, Ruohonen ST, Nuutinen S, Savontaus E, Loerakker S, Bayless KJ, Sjöqvist M, Bouten CVC, Eriksson JE, Sahlgren CM (2019) Vimentin regulates Notch signaling strength and arterial remodeling in response to hemodynamic stress. Scientific Reports 9:12415.  doi:10.1038/s41598-019-48218-w.

Wawruszak A, Luszczki JJ, Kalafut J, Okla K, Halasa M, Rivero-Müller A, Stepulak A (2019). Additive pharmacological interaction between cisplatin (CDDP) and histone deacetylase inhibitors (HDIs) in MDA-MB-231 triple negative breast cancer (TNBC) cells with altered Notch1 activity – an isobolographic analysis. International Journal of Molecular Sciences 20(15). pii: E3663. doi: 10.3390/ijms20153663.

Potorac I, Trehan A, Szymanska K, Fudvoye J, Thiry A, Huhtaniemi IT, Daly AF, Beckers A, Parent AS, Rivero-Müller A. (2019) Compound heterozygous mutations in the luteinizing hormone receptor signal peptide causing 46,XY disorder of sex development. Eur J Endocrinol. 2019 Jun 1. pii: EJE-19-0170.R1. doi: 10.1530/EJE-19-0170.

Wawruszak A, Kalafut J, Okon E, Czapinski J, Halasa M, Przybyszewska A, Miziak P, Okla K, Rivero-Muller A, Stepulak A (2019) Histone Deacetylase Inhibitors and Phenotypical Transformation of Cancer Cells. Cancers 11(2). pii: E148. doi: 10.3390/cancers11020148.

Szymańska K, Kałafut J, Przybyszewska A, Paziewska B, Kiełbus M, Rivero-Müller A (2018) FSHR Trans-Activation and Oligomerization. Frontiers in Endocrinology 9:760.

Szymańska K, Kałafut J, Rivero-Müller A (2018) The gonadotropin system, lessons from animal models and clinical cases. Minerva Ginecologica 70(5):561-587. doi: 10.23736/S0026-4784.18.04307-1.

Paramonov VM, Desai D, Kettiger H, Mamaeva V, Rosenholm JM, Sahlgren C, Rivero-Müller A (2018) Targeting Somatostatin Receptors By Functionalized Mesoporous Silica Nanoparticles – Are We Striking Home?. Nanotheranostics 2(4): 320-347. doi: 10.7150/ntno.23826. (

Kiełbus M, Czapiński J, Odrzywolski A, Stasiak G, Szymańska K, Kałafut J, Kos M, Giannopoulos K, Stepulak A, Rivero-Müller A. (2018) Optogenetics in cancer drug discovery. Expert Opinion on Drug Discovery 13(5):459-472. doi: 10.1080/17460441.2018.1437138  ( )

Doroszko M, Chrusciel M, Stelmaszewska J, Slezak T, Rivero-Müller A, Padzik A, Anisimowicz S, Wolczynski S, Huhtaniemi I, Toppari J, Rahman N (2017) Luteinizing hormone induced GATA4 expression promotes adrenocortical tumorigenesis in gonadectomized female mice. Cellular Physiology and Biochemistry 42:1064-1076.

Alam P, Sanka I, Alam LP, Wijaya S, Niken SNH, Rivero-Müller A (2017). Characterising the microarchitectures of the snapping shrimp plunger elucidates potential for thermomechanical damage tolerance. Zoology Nov 7. pii: S0944-2006(17)30110-1. doi: 10.1016/j.zool.2017.11.001.   One of the figures of this article was selected as the cover image of the Journal’s print version.

Wicaksono A, Hidayat S, Retnoaji B, Rivero-Müller A, and Alam P (2017) A mechanical piston action may assist pelvic–pectoral fin antagonism in tree-climbing fish. J Mar Biol Assoc U.K.

Antfolk D, Sjöqvist M, Cheng F, Isoniemi K, Duran CL, Rivero-Müller A, Antila Ch, Niemi R, Landor S, Bouten C, Bayless KJ, Eriksson JE and Sahlgren C (2017) Selective regulation of Notch ligands during angiogenesis is mediated by vimentin. Proc Natl Acad Sci U S A 114(23):E4574-E4581. doi: 10.1073/pnas.1703057114.

Czapiński J, Kiełbus M, Kałafut J, Kos M, Stepulak A, and Rivero-Müller A (2017) How to train a cell: cutting-edge molecular tools. Front Chem. 10;5:12. doi: 10.3389/fchem.2017.00012

Iulia Potorac*, Adolfo Rivero-Muller*, Ashutosh Trehan*, Michal Kielbus, Krzysztof Jozwiak, Francois Pralong, Aicha Hafidi, Albert Thiry, Jean-Jacques Menage, Ilpo T Huhtaniemi, Albert Beckers, and Adrian F Daly (2016) A vital region for human glycoprotein hormone trafficking revealed by an LHB mutation. J Endocrinol, doi:10.1530/JOE-16-0384.              One of the figures of this article was selected as the cover image of the Journal’s print version ( (Awarded the Society for Endocrinology’s five Journal Awards, given to the best papers published in Journal of Endocrinology, Journal of Molecular Endocrinology, Endocrine-Related Cancer, Clinical Endocrinology and Endocrine Connections in 2016).

Guz M, Rivero-Müller A, Okon E, Stenzel-Bembenek A, Polberg K, Slomka M, and Stepulak A (2014) MicroRNAs in lung cancer: clinical importance and potential as biomarkers. Disease Markers 2014:218169. doi: 10.1155/2014/218169.

Misiorek JO, Lähdeniemi IAK, Nyström JH, Paramonov VM, Gullmets JA, Saarento H, Rivero-Müller A, Husøy T, Taimen P, and Toivola DN (2016) Keratin 8-deletion induced colitis predisposes to murine colorectal cancer enforced by the inflammasome and IL-22 pathway. Carcinogenesis 37(8):777-86. doi: 10.1093/carcin/bgw063.

Sanka I, Suyono EA, Rivero-Müller A, and Alam P (2016) Carapace surface architectures facilitate camouflage of the decorator crab Tiarinia cornigera. Acta Biomaterialia S1742-7061(16)30239-2. doi: 10.1016/j.actbio.2016.05.021.

Trehan A, Kiełbus M, Czapinski J, Stepulak A, Huhtaniemi I, and Rivero-Müller A (2016) REPLACR-mutagenesis, a one-step method for site-directed mutagenesis by recombineering. Scientific Reports 6: 19121 (doi:10.1038/srep19121).

Paramonov VM, Mamaeva V, Sahlgren C, and Rivero-Muller A (2015) Genetically-encoded tools for cAMP probing and modulation in living systems. Front. Pharmacol. 6:196. doi: 10.3389/fphar.2015.00196

Véliz DS, Alam C, Nietzel T, Wyborski R, Rivero-Müller A, and Alam P (2015) Diatom-inspired skeletonisation of insulin – Mechanistic insights into crystallisation and extracellular bioactivity. Colloids Surf B Biointerfaces 133:140-7. doi: 10.1016/j.colsurfb.2015.05.047.

Rivero-Müller A, Potorac I, Pintiaux A, Daly A, Thiry A, Rydlewski C, Nisole M, Parent A-S, Huhtaniemi I, and Beckers A (2015) A novel inactivating mutation of the luteinizing hormone/chorionic gonadotrophin receptor (LHCGR) with an impaired membrane trafficking leading to Leydig cell hypoplasia type 1. European Journal of Endocrinology 172(6):K27-K36

Król SK, Kiełbus M, Rivero-Müller A, and Stepulak A (2015) Comprehensive Review on Betulin As A Potent Anti-cancer Agent. BioMed Res Int 2015:584189.

Trehan A, Rotgers E, Coffey ET, Huhtaniemi I, and Rivero-Müller A (2014) CANDLES Assay for monitoring GPCR induced cAMP generation in cell cultures. Cell Commun Signal 12:70.

Waclawik A, Rivero-Müller A, Rahman NA, and Ziecik AJ (2015) Functional consequences of knocking down porcine prostaglandin synthases in the SK-6 swine kidney cell line. Reprod Biol 15(1):42-7.

Rotgers E, Rivero-Müller A, Nurmio M, Parvinen M, Guillou F, Huhtaniemi I, Kotaja N, Bourguiba-Hachemi S, Toppari J (2014) Retinoblastoma protein (RB) interacts with E2F3 to control terminal differentiation of Sertoli cells. Cell Death and Disease 5: e1274; doi:10.1038/cddis.2014.232.

Guz M, Rivero-Müller A, Okon E, Stenzel-Bembenek A, Polberg K, Slomka M, and Stepulak A (2014) MicroRNAs in lung cancer: clinical importance and potential as biomarkers. Disease Markers 2014:218169. doi: 10.1155/2014/218169.

Mäkelä J-A, Toppari J, Rivero-Muller A, Ventelä S (2014) Reconstruction of mouse testicular cellular microenvironments in long term seminiferous tubule culture. PLoS ONE March 11 (DOI: 10.1371/journal.pone.0090088)

Chrusciel M, Vuorenoja S, Mohanty B, Rivero-Muller A, Li X, Toppari J, Huhtaniemi I, and Rahman NA (2013) GATA-4 overexpression induces adrenocortical tumorigenesis in C57Bl/6N mice. J Cell Sci 126(8):1845-57.

Rahman NA, Coelingh Bennink HJT, Chrusciel M, Sharp V, Zimmerman Y, Dina R, Li X, Ellonen A, Rivero-Muller A, Dilworth S, Ghaem-Maghami S, Vainio O, Huhtaniemi I (2012) A novel treatment strategy for ovarian cancer based on immunization against zona pellucida protein (ZP) 3. FASEB J 26(1):324-33. 

  • Selected by Faculty 1000 (Burger H: 2011.

Ahtiainen P, Sharp V, Rulli S, Rivero-Muller A, Mamaeva V, Röyttä M, Huhtaniemi I (2010) Enhanced LH action in transgenic female mice expressing hCGβ subunit induces pituitary prolactinomas: the role of high progesterone levels. Endocr Relat Cancer 17: 611-621.

Peltoketo H, Rivero-Muller A, Ahtiainen P, Poutanen M, Huhtaniemi I (2010) Consequences of genetic manipulations of gonadotrophins and gonadotrophin receptors in mice. Ann Endocrinol (Paris) 71(3):170-6.

Rivero-Muller A, Chou Y-Y, Ji I, Lajic S, Hanyaloglu AC, Jonas K, Rahman N, Ji TH, Huhtaniemi I (2010) Rescue of defective G protein-coupled receptor function in vivo by intermolecular co-operation. Proc Natl Acad Sci U S A 107(5):2319-24.

Peuhu E, Rivero-Muller A, Stykki H, Torvaldson E, Holmbom T, Eklund P, Unkila M, Sjöholm R, Eriksson J E. (2010) Inhibition of Akt signaling by the lignan matairesinol sensitizes prostate cancer cells to TRAIL-induced apoptosis. Oncogene 29(6):898-908.

Vuorenoja S, Rivero-Muller A, Ziecik AJ, Huhtaniemi I, Toppari J, Rahman NA. (2008) Targeted therapy for adrenocortical tumors in transgenic mice through their LH receptor by Hecate-human chorionic gonadotropin beta conjugate. Endocr Relat Cancer 15(2):635-48.

Rivero-Muller A, Lajić S, Huhtaniemi I. (2007) Assisted Large Fragment Insertion by Red/ET-recombination (AL-FIRE) – An Alternative and Enhanced Method for Large Fragment Recombineering. Nucleic Acids Research 35(10):e78.

Rivero-Muller A, Vuorenoja S, Tuominen M, Waclawik A, Brokken LJ, Ziecik AJ, Huhtaniemi I, Rahman NA. (2007) Use of hecate-chorionic gonadotropin beta conjugate in therapy of lutenizing hormone receptor expressing gonadal somatic cell tumors. Mol Cell Endocrinol 269(1-2):17-25.

Vuorenoja S, Rivero-Muller A, Kiiveri S, Bielinska M, Heikinheimo M, Wilson DB, Huhtaniemi IT, Rahman NA (2007)  Adrenocortical tumorigenesis, luteinizing hormone receptor and transcription factors GATA-4 and GATA-6. Mol Cell Endocrinol 269(1-2):38-45.

An BS, Selva DM, Hammond GL, Rivero-Muller A, Rahman N, Leung PC (2006) Steroid receptor coactivator-3 is required for progesterone receptor trans-activation of target genes in response to gonadotropin-releasing hormone treatment of pituitary cells. J Biol Chem 281(30):20817-24.

Waclawik A, Rivero-Muller A, Blitek A, Kaczmarek MM, Brokken LJ, Watanabe K, Rahman NA, Ziecik AJ (2006) Molecular cloning and spatiotemporal expression of prostaglandin F synthase and microsomal prostaglandin E synthase-1 in porcine endometrium. Endocrinology 147(1):210-21.

Rivero-Muller A, De Vizcaya-Ruiz A, Plant N, Ruiz L, Dobrota M (2006) Mixed chelate copper complex, Casiopeina IIgly, binds and degrades nucleic acids: A mechanism of cytotoxicity. Chem Biol Interact 165(3):189-99.

Wang Y, Suominen JS, Parvinen M, Rivero-Muller A, Kiiveri S, Heikinheimo M, Robbins I, Toppari J (2005) The regulated expression of c-IAP1 and c-IAP2 during the rat seminiferous epithelial cycle plays a role in the protection of germ cells from Fas-mediated apoptosis. Mol Cell Endocrinol 245(1-2): 111-120.

Bodek G, Vierre S, Rivero–Muller A, Huhtaniemi I, Ziecik AJ, and Rahman NA (2005) A novel targeted therapy of Leydig and granulosa cell tumors through the luteinizing hormone receptor using a hecate-chorionic gonadotropin-b conjugate in transgenic mice. Neoplasia 7(5) 497-508.

Rahman NA, Kiiveri S, Rivero-Muller A, Levallet J, Vierre S, Kero J, Wilson DB, Heikinheimo M, Huhtaniemi I. (2004) Adrenocortical tumorigenesis in transgenic mice expressing the inhibin {alpha}-subunit promoter/SV40 virus T-antigen transgene: Relationship between ectopic expression of luteinizing hormone receptor and transcription factor GATA-4. Mol Endocrinol 18(10):2553-6.

De Vizcaya-Ruiz A, Rivero-Muller A, Ruiz-Ramirez L, Howarth JA, Dobrota M.  (2003). Hematotoxicity response in rats by the novel copper-based anticancer agent: casiopeina II. Toxicology 194(1-2):103-13.

Tran SE, Meinander A, Holmstrom TH, Rivero-Muller A, Heiskanen KM, Linnau EK, Courtney MJ, Mosser DD, Sistonen L, Eriksson JE. (2003) Heat stress downregulates FLIP and sensitizes cells to Fas receptor-mediated apoptosis. Cell Death Differ 10(10):1137-47.

DeVizcaya-Ruiz, A., Rivero-Muller, A., Ruiz-Ramirez, L., Kass, G.E.N., Kelland, L.R., Orr, R.M. and Dobrota, M. (2000). Induction of Apoptosis by a Novel Copper-based Anticancer Compound – Casiopeina II in L1210 and CH1 Cells. Toxicology in Vitro 14: 1-5.

Sumano H, Gracia I, Capistrán A, Meade G, Rivero A, Ruiz-Ramírez L. (1995) Use of ambroxol and bromhexine as mucolytics for enhanced diffusion of furaltadone into tracheobronchial secretions in broilers. Br Poult Sci. 36(3):503-7.

Rivero-Müller A, and Huhtaniemi I (2010) Functional Relevance of GPCR Dimers. GIT Laboratory Journal (7-8): 26-27.

Rivero-Müller A (2015) Science Can Still Captivate Us All. Biochemistry & Modern Applications 2015, 1:1

Llano M, Muller G, Rivero A. National book on Chemistry (2010-2011), secondary school 3rd level (National Curriculum). Ediciones SM (in Spanish).

Rivero-Muller A; Jonas KC; Hanyaloglu AC; Huhtaniemi I (2013) Di/Oligomerization of GPCRs – Mechanisms and Functional Significance. Prog Mol Biol Transl Sci 117, 163. (5,700 words).

Jonas KC; Rivero-Muller A; Huhtaniemi IT; Hanyaloglu AC (2013) G Protein-Coupled Receptor Transactivation: From Molecules to Mice. Methods in Cell Biology 117:433-50. DOI:10.1016/B978-0-12-408143-7.00023-2. (5,600 words).

Trehan A; Jonas KC; Huhtaniemi IT; Hanyaloglu AC; Rivero-Muller A  (2014) Rescue of Defective G Protein–Coupled Receptor Function by Intermolecular Cooperation. G Protein-Coupled Receptor Genetics. Methods in Pharmacology and Toxicology pp 239-255. DOI 10.1007/978-1-62703-779-2_13. (5,100 words).

Casarini L, Huhtaniemi I, Simoni M, Rivero-Müller A (2017) Gonadotropin Receptors. Endocrinology of the Testis and Male Reproduction, Springer International Publishing. pp 1-46   (14,000 words).

Huhtaniemi I and Rivero-Müller A (2019) Mutations and Polymorphisms, and their Functional Consequences, in Gonadotropin and Gonadotropin Receptor Genes. The Ovary, 3rd edition, Elsevier.

Rivero-Müller A & Huhtaniemi I (2021) Impact of genetic variants in gonadotropins and their receptors on the diagnosis and management of the infertile patient.


On media

Articles highlighted in different media:

Rivero-Muller et al (2010) PNAS. Recommended by Faculty1000. Highlighted in: Science SignalingPNAS, and Trends in Biochemical Sciences

Rahman et al (2012) FASEB J. Recommended by Faculty 1000 (Burger H: 2011)

Trehan et al (2016) Sci Rep. Highlighted by Addgene

Potorac et al (2016) J Endocrinol. Cover image of the Journal’s print version

Award for best article in the 5 journals of the Society of Endocrinology

Alam et al (2018) Cover image of Zoology (2018).

Onet Lublin (in Polish) on the job as scientist

Local TVP3 Lublin interview (broadcasted on 28/Nov/2017):

Local TVP3 Lublin interview (broadcasted on 12/Dec/2017):

On integration, Local TVP3 (May 2019):


Research funding

Our research has been supported by the Polish National Science Centre and the Medical University of Lublin Grant for Young Scientist.